ODCs

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4 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
3 signs/symptoms

Pediatric systemic lupus erythematosus

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	IRAK1	(0.9)	IRAK4

Citations in the biomedical literature:

Pediatric systemic lupus erythematosus		Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency
	Synonym(s): - SLE, pediatric onset		Synonym(s): - IRAK4 deficiency

	Classification (Orphanet): - Rare neurologic disease - Rare renal disease - Rare respiratory disease - Rare systemic or rheumatologic disease		Classification (Orphanet): - Rare genetic disease - Rare immune disease

	Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: (no data available)		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal recessive

	External references: No OMIM references No MeSH references		External references: 1 OMIM reference - No MeSH references

Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency
	Very frequent - Anomalies of the lymphatic system - Immunodeficiency / increased susceptibility to infections / recurrent infections - Polynuclear cells / neutrophils anomalies / neutropenia
Pediatric systemic lupus erythematosus
(no data available)